{"id":3692,"date":"2022-08-12T11:39:46","date_gmt":"2022-08-12T11:39:46","guid":{"rendered":"https:\/\/apd2022.net\/?post_type=lectures&#038;p=3692"},"modified":"2022-08-24T16:30:15","modified_gmt":"2022-08-24T16:30:15","slug":"premature-menopause-and-risk-of-cardiovascular-disease-a-meta-analysis","status":"publish","type":"lectures","link":"https:\/\/apd2022.net\/en\/lectures\/premature-menopause-and-risk-of-cardiovascular-disease-a-meta-analysis\/","title":{"rendered":"Premature Menopause and Risk of Cardiovascular Disease: A Meta-Analysis"},"content":{"rendered":"\n<p><strong><em>Aim<\/em><\/strong><strong>:<\/strong> The aim of this study was to carry out a meta-analysis to assess the evidence for the association of premature menopause with coronary heart disease, stroke, and total CVD, and to obtain a quantitative estimate of this risk.<\/p>\n\n\n\n<p><strong><em>Methods<\/em><\/strong><strong>:<\/strong> A literature search of observational studies was performed using electronic databases such as Google Scholar, PubMed, JSTOR, etc. Fifteen studies on premature menopause in relation to cardiovascular outcomes were selected. Random-effect model was used to pool relative risk (RR) estimates and corresponding 95% confidence intervals (CI). Between-study heterogeneity was assessed using Cochran\u2019s Q and I2 statistics. Egger&#8217;s test, Begg test, and funnel plot asymmetry were used to detect potential publication bias. Sensitivity analysis using the leave-one-out method was performed to examine whether the result was strongly influenced by a specific study. In addition, subgroup analysis was performed for geographical region, study quality, publication year, reference group, and adjustment for potential cofounders. The differences among subgroups were assessed by meta-regression analysis.<\/p>\n\n\n\n<p><strong><em>Results<\/em><\/strong><strong>:<\/strong> The pooled RR estimate for the association between premature menopause and coronary heart disease was 1.871 (95% CI: 0.497-2.338, p &lt; 0.001). The finding of an elevated risk of coronary heart disease was consistently observed in almost all of the stratified analyses. Furthermore, the pooled RR of stroke was 1.433 (95% CI: 1.062-1.934, p = 0.019). The meta-analysis gave a pooled RR of 1.520 (95% CI: 1.198-1.928, p = 0.001), which indicates a 52 percent increase in the risk of overall CVD among women with premature menopause.<\/p>\n\n\n\n<p><strong><em>Conclusion<\/em><\/strong><strong>:<\/strong> The study found an elevated risk of adverse cardiovascular outcomes in women experiencing premature menopause, especially a higher risk of coronary heart disease. This might have significant clinical and public health implications, emphasizing the need for close monitoring of premature menopausal women in clinical practices.<\/p>\n","protected":false},"template":"","_links":{"self":[{"href":"https:\/\/apd2022.net\/en\/wp-json\/wp\/v2\/lectures\/3692"}],"collection":[{"href":"https:\/\/apd2022.net\/en\/wp-json\/wp\/v2\/lectures"}],"about":[{"href":"https:\/\/apd2022.net\/en\/wp-json\/wp\/v2\/types\/lectures"}],"wp:attachment":[{"href":"https:\/\/apd2022.net\/en\/wp-json\/wp\/v2\/media?parent=3692"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}